反应详情

8.8 g of 4-(4-chloro-3-chlorosulfonylphenyl)-3-methyl-2-methylimino-1,3-thiazolidine-4-ol-hydrobromide were reacted as prescribed in Example 76 with 5 g of triethyl amine and 3.5 g of 2,4-dimethoxybenzyl amine and worked up. After treating with water, the amorphous 4-[4-chloro-3-(2,4-di-methoxybenzylsulfamoyl)-phenyl]-3-methyl-2-methylimino-1,3-thiazolidine-4-ol was extracted with 70 ml of ethyl acetate, dried over sodium sulfate and the solvent was acidified with ethanolic hydrochloric acid (15%). The amorphous precipitate end product was crystallized under isopropanol. Melting point: 163° C (decomposition).

1. extractionthe amorphous 4-[4-chloro-3-(2,4-di-methoxybenzylsulfamoyl)-phenyl]-3-methyl-2-methylimino-1,3-thiazolidine-4-ol was extracted with 70 ml of ethyl acetate
2. dry with materialdried over sodium sulfate
3. customThe amorphous precipitate end product was crystallized under isopropanol