Hydrochloric Acid → HCID 22760437, compound

HRID 461196Notes

Reaction equation

HRID 461196 reaction equation
Br.C(N1C(C2C=CC([Cl:16])=C(S(=O)(=O)N(C)C)C=2)(O)CSC1=NCC)C.[CH2:26]([N:28]1[C:32]([C:34]2[CH:39]=[CH:38][C:37]([Cl:40])=[C:36]([S:41](=[O:46])(=[O:45])[N:42]([CH3:44])[CH3:43])[CH:35]=2)([OH:33])[CH2:31][S:30][C:29]1=[N:47][CH2:48][CH3:49])[CH3:27].Cl>>[ClH:16].[CH2:26]([N:28]1[C:32]([C:34]2[CH:39]=[CH:38][C:37]([Cl:40])=[C:36]([S:41](=[O:45])(=[O:46])[N:42]([CH3:43])[CH3:44])[CH:35]=2)([OH:33])[CH2:31][S:30][C:29]1=[N:47][CH2:48][CH3:49])[CH3:27]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 22760425HCID 22760425, compoundHCID 22760426HCID 22760426, compound

Product 1

HCID 22760437HCID 22760437, compound

Procedure

10 g of 3-ethyl-2-ethylimino-4-(4-chloro-3-dimethylsulfamoylphenyl)-1,3-thiazolidine-4-ol-hydrobromide were reacted according to Example 2c) and the yellow precipitate of 3-ethyl-2-ethylimino-4-(4-chloro-3-dimethylsulfamoylphenyl)-1,3-thiazolidine-4-ol was rapidly filtered off. The compound so obtained was treated according to Example 3c) with ethanolic hydrochloric acid and the end product was precipitated by adding diisopropyl ether. The solvent was decanted, 200 ml of water were added to the amorphous residue and the aqueous solution was lyophilized. Colorless amorphous solid body, decomposition beginning at 134° C, γ C=N 1615 cm-1.

Workup

  1. filtrationwas rapidly filtered off
  2. customThe compound so obtained
  3. additionwas treated
  4. customthe end product was precipitated
  5. additionby adding diisopropyl ether
  6. customThe solvent was decanted
  7. addition200 ml of water were added to the amorphous residue
  8. customat 134° C

Sources & evidence

ORD record
ord-dd0f139163df4b128840b1830ef68a5d
Source dataset
uspto-grants-1977_12
Patent number
US04061761

Reaction notes

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