Sodium Bicarbonate → HCID 178486131, compound

HRID 461199Notes

Reaction equation

HRID 461199 reaction equation
Br.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([OH:17])[C:13]3=[N:14][CH2:15][NH:16][C:12]3=[N:11][S:10]2)=[CH:5][C:4]=1[S:18](=[O:23])(=[O:22])[N:19]([CH3:21])[CH3:20].C(=O)(O)[O-].[Na+]>O>[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([OH:17])[C:13]3=[N:14][CH2:15][NH:16][C:12]3=[N:11][S:10]2)=[CH:5][C:4]=1[S:18](=[O:22])(=[O:23])[N:19]([CH3:20])[CH3:21]

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 178419594HCID 178419594, compound

Product 1

HCID 178486131HCID 178486131, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

7.3 g of 3-(4-chloro-3-dimethylsulfamoylphenyl)-3-hydroxy-2,3,5,6-tetrahydro-imidazo[2,1-]thiazol-hydrobromide were dissolved in 100 ml of water at 35° - 40° C. After adding a solution of 6 g of sodium bicarbonate in 200 ml of water, the mixture was stirred for 15 minutes at room temperature and the end product was filtered off. Colorless crystals, melting point: 154° C (decomposition).

Workup

  1. filtrationthe end product was filtered off

Sources & evidence

ORD record
ord-fb23e49f5c4f4c8ea6b43c3c9dca29a7
Source dataset
uspto-grants-1977_12
Patent number
US04061761

Reaction notes

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