5-Bromo-2-chloronitrobenzene → 2-Chloro-5-bromoaniline

HRID 461206Notes

Reaction equation

HRID 461206 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:11])=[C:6]([N+:8]([O-])=O)[CH:7]=1.[H][H]>CO.[Ni]>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:11])=[C:6]([CH:7]=1)[NH2:8]

Participants

5

Reactant 2

HCID 8179745-Bromo-2-chloronitrobenzeneHCID 178418361HCID 178418361, compound

Product 1

HCID 38307312-Chloro-5-bromoaniline

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

90 g of 5-bromo-2-chloronitrobenzene were hydrogenated in 500 ml of methanol at room temperature and under normal pressure with Raney-Nickel as catalyst and hydrogen. Colorless crystals, melting point: 47° C.

Sources & evidence

ORD record
ord-5dec04d979244d97a4d35c7d8daaa9e1
Source dataset
uspto-grants-1977_12
Patent number
US04061761

Reaction notes

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