4'-Fluoro-3'-nitroacetophenone → 3'-Amino-4'-fluoroacetophenone

HRID 461208Notes

Reaction equation

HRID 461208 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][C:3]=1[N+:11]([O-])=O>CO.[Ni]>[NH2:11][C:3]1[CH:4]=[C:5]([C:8](=[O:10])[CH3:9])[CH:6]=[CH:7][C:2]=1[F:1]

Participants

4

Reactant 1

HCID 27346124'-Fluoro-3'-nitroacetophenone

Product 1

HCID 106069533'-Amino-4'-fluoroacetophenone

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

39 g of 4'-fluoro-3'-nitroacetophenone, melting point: 44° C, were hydrogenated in 390 ml of methanol at 20 atm. and 40° C in the presence of Raney-Nickel to give the 3'-amino-4'-fluoro-acetophenone, melting point: 70° C).

Sources & evidence

ORD record
ord-f99e5ea552214f1dbffc37f86dab6365
Source dataset
uspto-grants-1977_12
Patent number
US04061761

Reaction notes

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