反应详情

温度

175 °C

A mixture of 24.4 grams (0.2 mole) of N-methyl-o-phenylenediamine and 14.4 grams (0.24 mole) of urea was prepared. The mixture was stirred for 16 hours in an oil bath maintained at 175° C. The reaction mixture then was cooled to about 80° C., 250 ml. of alcohol were added, and the mixture was refluxed for 20 minutes and then was filtered while hot. The filtrate was allowed to cool to room temperature and was refrigerated overnight. The crystals that formed were filtered, dried, and recrystallized from water to obtain 7.84 grams of 3-methyl-2-oxobenzimidazole, melting point 188°-189° C.

1. customwas prepared
2. temperatureThe reaction mixture then was cooled to about 80° C.
3. temperaturethe mixture was refluxed for 20 minutes
4. filtrationwas filtered while hot
5. temperatureto cool to room temperature
6. waitwas refrigerated overnight
7. customThe crystals that formed
8. filtrationwere filtered
9. customdried
10. customrecrystallized from water