反应详情

A solution containing 5.1 g (0.025 mole) of 2,4-dichlorophenoxyacetaldehyde, 4.25 g (0.028 mole) of mandelic acid, and 10.0 g (0.07 mole) of boron trifluoide etherate in 250 ml of ether was allowed to stir for 2 hours at ambient temperature, washed with aqueous sodium carbonate and water, dried and concentrated. The residual solid was purified by silica chromatography to give 2.7 g of 2-(2,4-dichloro-phenoxymethyl)-5-phenyl-1,3-dioxolan-4-one, trans isomer, having a melting point of 68°-71°.

1. washwashed with aqueous sodium carbonate and water
2. customdried
3. concentrationconcentrated
4. customThe residual solid was purified by silica chromatography