Hydrochloric Acid → HCID 70636247, compound

HRID 461316Notes

Reaction equation

HRID 461316 reaction equation
[C:1]([C:3](=[C:8]1[C@:25]2([CH3:26])[C@H:11]([C@H:12]3[C@H:22]([CH2:23][CH2:24]2)[C@:20]2([CH3:21])[C:15]([CH2:16][C@@H:17]([OH:27])[CH2:18][CH2:19]2)=[CH:14][CH2:13]3)[CH2:10][CH2:9]1)[CH2:4][C:5]([O-:7])=[O:6])#[N:2].[Na+].Cl>O>[C:1]([C:3](=[C:8]1[C@:25]2([CH3:26])[C@H:11]([C@H:12]3[C@H:22]([CH2:23][CH2:24]2)[C@:20]2([CH3:21])[C:15]([CH2:16][C@@H:17]([OH:27])[CH2:18][CH2:19]2)=[CH:14][CH2:13]3)[CH2:10][CH2:9]1)[CH2:4][C:5]([OH:7])=[O:6])#[N:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86735254HCID 86735254, compound

Product 1

HCID 70636247HCID 70636247, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 20 parts of sodium 20-cyano-3β-hydroxypregna-5,17(20)-diene-21-carboxylate in 1000 parts of warm water is acidified with 100 parts of 4% hydrochloric acid. Approximately 1 hour later, the precipitate which has formed is separated by filtration, washed with water, dried in vacuo, and recrystallized from methanol to give 20-cyano-3β-hydroxypregna-5,17(20)-diene-21-carboxylic acid melting at 245°-250°. The product has the formula ##STR3##

Workup

  1. customApproximately 1 hour later, the precipitate which has formed
  2. customis separated by filtration
  3. washwashed with water
  4. customdried in vacuo
  5. customrecrystallized from methanol

Sources & evidence

ORD record
ord-8f9ef3ced3e447c3ba730a371f9ce9a8
Source dataset
uspto-grants-1977_12
Patent number
US04062843

Reaction notes

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