N-Methylmaleimide → HCID 12235842, compound

HRID 461326Notes

Reaction equation

HRID 461326 reaction equation
[CH:1]1[C:6]2[N:7]=[C:8]3[CH:15]=[CH:14][CH:13]=[CH:12][N:9]3[CH2:10][O:11][C:5]=2[CH:4]=[CH:3][CH:2]=1.[CH3:16][N:17]1[C:21](=[O:22])[CH:20]=[CH:19][C:18]1=[O:23]>C1(C)C(C)=CC=CC=1>[CH3:16][N:17]1[C:21](=[O:22])[CH:20]2[CH:19]([CH:15]3[CH2:14][CH2:13][CH:12]2[N:9]2[CH2:10][O:11][C:5]4[CH:4]=[CH:3][CH:2]=[CH:1][C:6]=4[N:7]=[C:8]32)[C:18]1=[O:23]

Participants

4

Reactant 2

HCID 70261N-MethylmaleimideHCID 12235832HCID 12235832, compound

Product 1

HCID 12235842HCID 12235842, compoundYield 78.1%

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

A mixture of 6H-pyrido[1,2-c][1,3,5]benzoxadiazepine (1.98 g) and N-methylmaleimide (1.68 g) in 50 ml of xylene is heated under reflux conditions for 23 hours. The reaction mixture is allowed to cool to room temperature and then allowed to stand in a refrigerator for 5 hours. The crude product is collected, washed with xylene and dried in vacuo for about 16 hours at room temperature and for 6 hours at 110° C to give 2.43 g of the title compound, melting point 252°-253° C.

Workup

  1. temperatureis heated under reflux conditions for 23 hours
  2. customThe crude product is collected
  3. washwashed with xylene
  4. customdried in vacuo for about 16 hours at room temperature and for 6 hours at 110° C

Sources & evidence

ORD record
ord-730c3062b8b646ccaa09acc01c7d39b4
Source dataset
uspto-grants-1977_12
Patent number
US04062852

Reaction notes

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