Butanethiol → HCID 86735255, compound

HRID 461335Notes

Reaction equation

HRID 461335 reaction equation
[C:1]([N:3]1[CH2:8][CH2:7][N:6]([C:9]2[N:18]=[C:17]([NH2:19])[C:16]3[C:11](=[CH:12][C:13]([O:22][CH3:23])=[C:14]([O:20][CH3:21])[CH:15]=3)[N:10]=2)[CH2:5][CH2:4]1)#[N:2].[CH2:24]([SH:28])[CH2:25][CH2:26][CH3:27]>COCCOCCOC>[NH2:19][C:17]1[C:16]2[C:11](=[CH:12][C:13]([O:22][CH3:23])=[C:14]([O:20][CH3:21])[CH:15]=2)[N:10]=[C:9]([N:6]2[CH2:7][CH2:8][N:3]([C:1]([S:28][CH2:24][CH2:25][CH2:26][CH3:27])=[NH:2])[CH2:4][CH2:5]2)[N:18]=1

Participants

4

Reactant 2

HCID 8012ButanethiolHCID 213933662-(4-Cyanopiperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline

Product 1

HCID 86735255HCID 86735255, compound

Reagents, catalysts & solvents 1

HCID 8150DiglymeSolvent

Procedure

To a solution of 6.3 g. (0.02 mole) of 2-(4-cyanopiperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline in 75 ml. of diethyleneglycol dimethyl ether is added dropwise over 15 minutes a solution of 1.8 g. (0.02 mole) n-butyl mercaptan in 25 ml. of the same solvent. The resulting mixture is stirred at 20°-25° C. for 2 hours, then the solvent is removed in vacuo. The residue is triturated with ethyl ether, filtered and dried to obtain the title compound.

Workup

  1. customthe solvent is removed in vacuo
  2. customThe residue is triturated with ethyl ether
  3. filtrationfiltered
  4. customdried

Sources & evidence

ORD record
ord-0740c63d18bf44188875034d54927a23
Source dataset
uspto-grants-1977_12
Patent number
US04062844

Reaction notes

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