Methylamine → 1-benzyl-4-(morpholino)-5,6-dihydrobenzo-[5,6]cyclohepta[1,2-b]pyrazolo[4,3-e]pyridin-11(1H)one

HRID 461373Notes

Reaction equation

HRID 461373 reaction equation
[CH2:1]([N:8]1[C:16]2[N:15]=[C:14]3[C:17](=[O:26])[C:18]4[CH:25]=[CH:24][CH:23]=[CH:22][C:19]=4[CH2:20][CH2:21][C:13]3=[C:12](Br)[C:11]=2[CH:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:28]1[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1.CN>>[CH2:1]([N:8]1[C:16]2[N:15]=[C:14]3[C:17](=[O:26])[C:18]4[CH:25]=[CH:24][CH:23]=[CH:22][C:19]=4[CH2:20][CH2:21][C:13]3=[C:12]([N:28]3[CH2:33][CH2:32][O:31][CH2:30][CH2:29]3)[C:11]=2[CH:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 6329MethylamineHCID 8083MorpholineHCID 227577601-benzyl-4-bromo-5,6-dihydrobenzo[5,6]cyclohepta[1,2-b]pyrazolo[4,3-e]-pyridin-11(1H)one

Product 1

HCID 227577521-benzyl-4-(morpholino)-5,6-dihydrobenzo-[5,6]cyclohepta[1,2-b]pyrazolo[4,3-e]pyridin-11(1H)one

Procedure

By substituting the product of Example 11 in the procedure of Example 5 and substituting morpholine for the methylamine, 1-benzyl-4-(morpholino)-5,6-dihydrobenzo-[5,6]cyclohepta[1,2-b]pyrazolo[4,3-e]pyridin-11(1H)one is obtained.

Sources & evidence

ORD record
ord-aa78ba9afa354a78ac509e95fb22ae18
Source dataset
uspto-grants-1977_12
Patent number
US04062858

Reaction notes

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