反应详情

A suspension of methyl 5-benzyloxyindol-3-ylglyoxylate (10 g.) and sodium borohydride (3.7 g.) in isopropanol (100 ml.) was stirred and refluxed for 5 hours. The cooled mixture was diluted with water and extracted with dichloromethane. Evaporation of the extract gave a pale yellow oil which crystallised from a mixture of toluene and petroleum ether to give 5-benzyloxy-3-(2-hydroxyethyl)indole as a white crystalline powder m.p. 97°-98°.

1. temperaturerefluxed for 5 hours
2. extractionextracted with dichloromethane
3. customEvaporation of the extract
4. customgave a pale yellow oil which
5. customcrystallised from a mixture of toluene and petroleum ether