Acetic Acid → HCID 21393852, compound

HRID 461492Notes

Reaction equation

HRID 461492 reaction equation
[N+:1]([C:4]1[C:5]([C:14]([F:17])([F:16])[F:15])=[CH:6][CH:7]=[C:8]2[C:13]=1[CH:12]=[N:11][CH:10]=[CH:9]2)([O-])=O.C(O)(=O)C.[OH-].[NH4+]>C(O)C.O.[Zn]>[NH2:1][C:4]1[C:5]([C:14]([F:17])([F:15])[F:16])=[CH:6][CH:7]=[C:8]2[C:13]=1[CH:12]=[N:11][CH:10]=[CH:9]2

Participants

7

Reactant 3

HCID 176Acetic AcidHCID 14923Ammonium HydroxideHCID 21393813HCID 21393813, compound

Product 1

HCID 21393852HCID 21393852, compound

Reagents, catalysts & solvents 3

HCID 23994ZincCatalystHCID 702EthanolSolventHCID 962WaterSolvent

Procedure

According to the procedure in Example 12, 8-nitro-7-trifluoromethylisoquinoline is heated with zinc and acetic acid in ethanol and water on a steam bath for five minutes and the reaction mixture is cooled, made alkaline with aqueous ammonium hydroxide and extracted with ethyl acetate. Removing the solvent from the extract in vacuo gives, as the residue, 8-amino-7-trifluoromethylisoquinoline.

Workup

  1. temperaturethe reaction mixture is cooled
  2. extractionextracted with ethyl acetate
  3. customRemoving the solvent from the
  4. extractionextract in vacuo

Sources & evidence

ORD record
ord-cbc192a2737443b6ba56d1a71c7993ca
Source dataset
uspto-grants-1977_12
Patent number
US04062961

Reaction notes

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