Methylamine → HCID 21393864, compound

HRID 461497Notes

Reaction equation

HRID 461497 reaction equation
[C:1]([N:4]1[CH2:13][CH2:12][C:11]2[C:6](=[CH:7][C:8]([S:14](Cl)(=[O:16])=[O:15])=[CH:9][CH:10]=2)[CH2:5]1)(=[O:3])[CH3:2].[CH3:18][NH2:19]>>[C:1]([N:4]1[CH2:13][CH2:12][C:11]2[C:6](=[CH:7][C:8]([S:14](=[O:16])(=[O:15])[NH:19][CH3:18])=[CH:9][CH:10]=2)[CH2:5]1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 126069042-Acetyl-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride

Product 1

HCID 21393864HCID 21393864, compound

Procedure

2-Acetyl-7-chlorosulfonyl-1,2,3,4-tetrahydroisoquinoline was reacted with a concentrated aqueous solution of methylamine with cooling. The resulting solid was filtered and washed with water to give 2-acetyl-7-methylsulfamoyl-1,2,3,4-tetrahydroisoquinoline. Hydrolyzing in refluxing 10% hydrochloric acid by the procedure of Example 15 and then recrystallizing from methanol/ether gave 7-methylsulfamoyl-1,2,3,4-tetrahydroisoquinoline hydrochloride, m.p. 238°-240° C.

Workup

  1. temperaturewith cooling
  2. filtrationThe resulting solid was filtered
  3. washwashed with water

Sources & evidence

ORD record
ord-e23a9ce4b58c478d8112d7185aad587d
Source dataset
uspto-grants-1977_12
Patent number
US04062961

Reaction notes

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