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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 461499Generated: October 30, 2026

Hydrochloric Acid → 1,2,3,4-Tetrahydro-8-(trifluoromethyl)isoquinoline

https://huagongshe.com/reaction/461499

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant8-(Trifluoromethyl)isoquinolineHCID 21393819—
Product1,2,3,4-Tetrahydro-8-(trifluoromethyl)isoquinolineHCID 18176492—

Reaction Steps

Converting 8-trifluoromethylisoquinoline to the hydrochloride, m.p. 213°-216.5° C., then treating by the procedure of Example 9 gives 8-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04062961
Source datasetuspto-grants-1977_12
ORD IDord-51d56014b6d84322a6e9b8ed27f3042c
Source noteuspto-grants-1977_12