Hydrochloric Acid → 1,2,3,4-Tetrahydro-8-(trifluoromethyl)isoquinoline

HRID 461499Notes

Reaction equation

[F:1][C:2]([F:14])([F:13])[C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[CH:11]=[N:10][CH:9]=[CH:8]2.Cl>>[F:14][C:2]([F:1])([F:13])[C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[CH2:11][NH:10][CH2:9][CH2:8]2

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 213938198-(Trifluoromethyl)isoquinoline

Product 1

HCID 181764921,2,3,4-Tetrahydro-8-(trifluoromethyl)isoquinoline

Procedure

Converting 8-trifluoromethylisoquinoline to the hydrochloride, m.p. 213°-216.5° C., then treating by the procedure of Example 9 gives 8-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline.

Workup

additiontreating by the procedure of Example 9

Sources & evidence

ORD record: ord-51d56014b6d84322a6e9b8ed27f3042c
Source dataset: uspto-grants-1977_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04062961

Reaction notes

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