Benzoyl chloride → HCID 21393873, compound

HRID 461500Notes

Reaction equation

HRID 461500 reaction equation
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C-:10]#[N:11].[K+].[Cl:13][C:14]1[C:23]([Cl:24])=[C:22]2[C:17]([CH:18]=[CH:19][N:20]=[CH:21]2)=[CH:16][CH:15]=1>O>[C:1]([N:20]1[CH:19]=[CH:18][C:17]2[C:22](=[C:23]([Cl:24])[C:14]([Cl:13])=[CH:15][CH:16]=2)[CH:21]1[C:10]#[N:11])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 7412Benzoyl chlorideHCID 9032Potassium CyanideHCID 125950627,8-Dichloroisoquinoline

Product 1

HCID 21393873HCID 21393873, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Benzoyl chloride (0.4 mole) is added over three hours to a stirred mixture of potassium cyanide (0.6 mole) in 250 ml. of water and 7,8-dichloroisoquinoline (0.2 mole) maintained at 25° C. The mixture is stirred for one more hour, cooled and filtered. The product is recrystallized from ethanol and dried to yield 2-benzoyl-7,8-dichloro-1-cyano-1,2,-dihydroisoquinoline.

Workup

  1. temperaturecooled
  2. filtrationfiltered
  3. customThe product is recrystallized from ethanol
  4. customdried

Sources & evidence

ORD record
ord-fd594bbee24442cd8419107273637988
Source dataset
uspto-grants-1977_12
Patent number
US04062961

Reaction notes

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