Methanol → HCID 88815335, compound

HRID 461677Notes

Reaction equation

HRID 461677 reaction equation
[NH2:1][C@H:2]([C:8]([OH:10])=[O:9])[CH2:3][CH2:4][CH2:5][CH2:6][NH2:7].[OH:11][P:12]([F:15])([OH:14])=[O:13].O.CO>C(O)C>[P:12]([F:15])([OH:14])([OH:13])=[O:11].[NH2:1][C@H:2]([C:8]([OH:10])=[O:9])[CH2:3][CH2:4][CH2:5][CH2:6][NH2:7]

Participants

6

Reactant 4

HCID 887MethanolHCID 962WaterHCID 5962L-LysineHCID 24267Phosphorofluoridic acid

Product 1

HCID 88815335HCID 88815335, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

L-lysine monofluorophosphate was prepared by combining 29.2 grams of free-base lysine with 20 gm. (grams) of monofluorophosphoric acid in about 75 ml. of water. The resulting clear syrupy solution was poured into 750 ml. of a 50:50 mixture of methanol and ethanol (absolute) to precipitate the solid salt. The cake was collected after filtration and rinsed with methanol. The product (L-lysine monofluorophosphate) was then air dried. The L-lysine monofluorophosphate was tested in rat diets as described in Example I but at a level of 6.8 ppm fluoride. Caries reduction was 36%.

Workup

  1. additionThe resulting clear syrupy solution was poured into 750 ml
  2. customto precipitate the solid salt
  3. customThe cake was collected
  4. filtrationafter filtration
  5. washrinsed with methanol
  6. customair dried

Sources & evidence

ORD record
ord-ae0c6452811a4f19bc05971ba169c3d6
Source dataset
uspto-grants-1977_12
Patent number
US04064138

Reaction notes

Loading…