Methanol → HCID 178512939, compound

HRID 461678Notes

Reaction equation

HRID 461678 reaction equation
[NH2:1][C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:9])[NH2:8].[OH:13][P:14]([F:17])([OH:16])=[O:15].O.CO>C(O)C>[P:14]([F:17])([OH:16])([OH:15])=[O:13].[NH2:1][C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:8])[NH2:9]

Participants

6

Reactant 4

HCID 887MethanolHCID 962WaterHCID 24267Phosphorofluoridic acidHCID 178418600HCID 178418600, compound

Product 1

HCID 178512939HCID 178512939, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

L-arginine monofluorophosphate was prepared by combining 34.8 gm. of free-base L-arginine with 20 gm. of monofluorophosphoric acid in about 75 ml. of water. The resulting clear syrup was poured into 750 ml. of a mixture of methanol and ethanol. This was allowed to stand over night and the salt was collected by filtration. The resulting L-arginine monofluorophosphate was then rinsed with methanol and air dried.

Workup

  1. additionThe resulting clear syrup was poured into 750 ml
  2. waitto stand over night
  3. filtrationthe salt was collected by filtration
  4. washThe resulting L-arginine monofluorophosphate was then rinsed with methanol and air
  5. customdried

Sources & evidence

ORD record
ord-04641c77270a470094c99656595ec83f
Source dataset
uspto-grants-1977_12
Patent number
US04064138

Reaction notes

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