Phosphoric Acid → HCID 178506429, compound

HRID 461680Notes

Reaction equation

HRID 461680 reaction equation
[NH2:1][C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:9])[NH2:8].[FH:13].[P:14](=[O:18])([OH:17])([OH:16])[OH:15]>O>[P:14]([OH:18])([OH:17])([OH:16])=[O:15].[FH:13].[NH2:1][C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:8])[NH2:9]

Participants

5

Reactant 3

HCID 1004Phosphoric AcidHCID 14917Hydrofluoric AcidHCID 178418600HCID 178418600, compound

Product 1

HCID 178506429HCID 178506429, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

L-arginine hydrofluoride phosphate was prepared by combining 34.8 gm. of L-arginine (free-base) with 8 gm. of a 50% aqueous solution of hydrofluoride and 23.5 gm. of orthophosphoric acid. This was dissolved in about 75 ml. of water. The resulting syrup was poured into about 750 ml. of a methanol-ethanol mixture to precipitate the salt. After filtration the cake (L-arginine hydrofluoride phosphate) was rinsed with methanol and air dried.

Workup

  1. dissolutionThis was dissolved in about 75 ml
  2. additionThe resulting syrup was poured into about 750 ml
  3. customof a methanol-ethanol mixture to precipitate the salt
  4. filtrationAfter filtration the cake (L-arginine hydrofluoride phosphate)
  5. washwas rinsed with methanol and air
  6. customdried

Sources & evidence

ORD record
ord-fe822d50ea124da48ff5199a438e7a90
Source dataset
uspto-grants-1977_12
Patent number
US04064138

Reaction notes

Loading…