Phosphoric Acid → HCID 178506428, compound

HRID 461681Notes

Reaction equation

HRID 461681 reaction equation
[NH2:1][C@H:2]([C:9]([OH:11])=[O:10])[CH2:3][C:4]1[N:8]=[CH:7][NH:6][CH:5]=1.[FH:12].[P:13](=[O:17])([OH:16])([OH:15])[OH:14]>OCC(CO)O>[P:13]([OH:17])([OH:16])([OH:15])=[O:14].[FH:12].[NH2:1][C@H:2]([C:9]([OH:11])=[O:10])[CH2:3][C:4]1[N:8]=[CH:7][NH:6][CH:5]=1

Participants

5

Reactant 3

HCID 1004Phosphoric AcidHCID 14917Hydrofluoric AcidHCID 178419078HCID 178419078, compound

Product 1

HCID 178506428HCID 178506428, compound

Reagents, catalysts & solvents 1

HCID 753GlycerolSolvent3×

Procedure

A glycerol solution of L-histidine hydrofluoride phosphate was prepared by suspending 15.5 gm. of free-base L-histidine in 168 gm. of glycerol. Then 4 gm. of a 50% aqueous solution of hydrofluoric acid and 11.5 gm. of orthophosphoric acid were added. The mixture slowly dissolved over night to yield a slightly cloudy solution. The resulting solution was diluted to about 200 gm. with glycerol.

Workup

  1. dissolutionThe mixture slowly dissolved over night
  2. customto yield a slightly cloudy solution
  3. additionThe resulting solution was diluted to about 200 gm

Sources & evidence

ORD record
ord-6f97a0070d5f430fa0fed06dde59e836
Source dataset
uspto-grants-1977_12
Patent number
US04064138

Reaction notes

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