Sodium Hydroxide → HCID 86735291, compound

HRID 461690Notes

Reaction equation

HRID 461690 reaction equation
[CH:1]12[CH:7]([CH2:8][CH2:9][NH:10][C:11]([C:13]3[S:17][C:16]([O:18][CH:19]4OC(C)(C)N(C(C)(C)C)[C:20]4=[CH2:30])=[N:15][CH:14]=3)=[O:12])[CH:4]([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[OH-:31].[Na+]>C(OCC)(=O)C>[CH:1]12[CH:7]([CH2:8][CH2:9][NH:10][C:11]([C:13]3[S:17][C:16]([O:18][CH2:19][CH:20]([OH:31])[CH3:30])=[N:15][CH:14]=3)=[O:12])[CH:4]([CH2:3][CH2:2]1)[CH2:5][CH2:6]2

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 68117591HCID 68117591, compound

Product 1

HCID 86735291HCID 86735291, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

This example illustrates methods of converting the compounds of formula E into the compounds of formula C. In this example 1 g. of 5-(5-[2-(bicyclo[2.2.1]hept-7-yl)ethylaminocarbonyl]thiazol-2-yloxy)-methylene-N-t-butyl-2,2-dimethyloxazolidine is dissolved in 50 ml. of ethyl acetate and this solution is treated with aqueous 5% sodium hydroxide (20 ml.) at 20° C. The mixture is allowed to stand for 0.5 hours, washed three times with water, dried over magnesium sulfate and then evaporated to dryness affording 1-t-butyl-3-(5-[2-(bicyclo[2.2.1]hept-7-yl)ethylaminocarbonyl]thiazol-2-yloxy-propan-2-ol.

Workup

  1. washwashed three times with water
  2. dry with materialdried over magnesium sulfate
  3. customevaporated to dryness

Sources & evidence

ORD record
ord-7c56b7cb66544343b867deebfcb38628
Source dataset
uspto-grants-1977_12
Patent number
US04064135

Reaction notes

Loading…