反应详情

This example illustrates methods of preparing hydrochloride addition salts of the compound of formula C. In this example 1 g. of 1-t-butylamino-3-(5-[2-(bicyclo[2.2.1]hept-7-yl)ethylaminocarbonyl]thiazol-2-yloxy)propan-2-ol is dissolved in 10 ml. of ethyl ether at 20° C. A stream of gaseous anhydrous hydrogen chloride is passed over the surface of the solution until the supernatent liquid becomes colorless. The resulting precipitate is collected by filtration, washed with ethyl ether and then crystallized from methanol/diethyl ether, affording crystalline 1-t-butylamino-3-(5-[2-(bicyclo[2.2.1]hept-7-yl)ethylaminocarbonyl]thiazol-2-yloxy)-propan-2-ol hydrochloride, m.p. 161°-166° C.

1. customat 20° C
2. filtrationThe resulting precipitate is collected by filtration
3. washwashed with ethyl ether
4. customcrystallized from methanol/diethyl ether