反应详情

To a solution of tert-butyl {[5-(4-bromophenyl)-5H-imidazo[2,1-a]isoindol-5-yl]methyl}carbamate (575 mg) in dioxane (2 mL) was added a HCl solution (3.265 mL, 4 M in dioxane) and stirred at room temperature for 1.5 h. After this time 1.5 mL more HCl solution was added and stirring continued for another 3 h. The reaction mixture was then concentrated (azeotroped once from toluene) and dried under vacuum to give title compound as a white solid. Mass. found (M+H)+, 342.0.

1. stirringstirring
2. waitcontinued for another 3 h
3. concentrationThe reaction mixture was then concentrated (
4. customazeotroped once from toluene) and
5. customdried under vacuum