反应详情

To a stirred mixture of 30 parts of p-(2-thenoyl)hydratropic acid and 14 parts of (+)-α-methylbenzylamine in 200 parts of ethanol are added 50 parts of water. The precipitated salt is filtered off and crystallized from a mixture of ethanol and water (10 : 2 by volume), yielding the crude salt form. The fraction is recrystallized several times till constant rotation, from a mixture of ethanol and water (10 : 2 by volume), yielding (+)-p-(2-thenoyl)hydratropic acid α-methylbenzylamine; mp. 171.1° C.; [α](2.02% MeOH) = +13.55°.

1. filtrationThe precipitated salt is filtered off
2. customcrystallized from a mixture of ethanol and water (10 : 2 by volume)
3. customyielding the crude salt form
4. customThe fraction is recrystallized several times till constant rotation
5. additionfrom a mixture of ethanol and water (10 : 2 by volume)