Ethanol → (+)-p-(2-Thenoyl)hydratropic acid alpha-methylbenzylamine

Beteiligte Stoffe

Reaktionsschritte

To a stirred mixture of 30 parts of p-(2-thenoyl)hydratropic acid and 14 parts of (+)-α-methylbenzylamine in 200 parts of ethanol are added 50 parts of water. The precipitated salt is filtered off and crystallized from a mixture of ethanol and water (10 : 2 by volume), yielding the crude salt form. The fraction is recrystallized several times till constant rotation, from a mixture of ethanol and water (10 : 2 by volume), yielding (+)-p-(2-thenoyl)hydratropic acid α-methylbenzylamine; mp. 171.1° C.; [α](2.02% MeOH) = +13.55°.

Herkunft & Nachweise