HRID461761

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID18914200

未命名化合物

结构：CC(=O)C1(O)C2=C3C(=CC1N=Nc1ccc(C(=O)O)cc1)C[C@@H]1[C@@H]4C=C[C@@](O)(C(C)=O)[C@H](O2)[C@]34CCN1C

HCID86735292

未命名化合物

PRODUCTS

生成物

结构：CC(=O)[C@]1(O)C=C[C@H]2[C@H]3Cc4cc(N=Nc5ccc(C(=O)O)cc5)c(O)c5c4[C@@]2(CCN3C)[C@H]1O5

HCID136409755

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID14798

Sodium Hydroxide

HNaO

PROCEDURE

实验过程

A solution of 0.5g of 2-(4'carboxyphenylazo)-3,6-diacetylmorphine in 10 ml 0.1 N NaOH was stirred at room temperature and examined hourly by silica gel TLC for the presence of the monoacetyl derivative, the solvent system being methylene chloride: methanol: water: acetic acid (80:20:1:1) and the rf value for azomonoacetyl morphine 0.39. When TLC showed most of the starting material to have hydrolyzed the reaction mixture was concentrated and passed down a silica gel column. The fraction containing the desired product was evaporated to dryness to give 2-(4'carboxyphenylazo) -6 acetyl morphine.

WORKUP

后处理

concentrationwas concentrated
additionThe fraction containing the desired product
customwas evaporated to dryness

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d59f681817c547c0beba15d2d5cc8863
来源数据集: uspto-grants-1977_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04064228
来源说明: uspto-grants-1977_12

反应 SMILES

[C:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]=[N:11][CH:12]2[C:25](C(=O)C)([OH:26])[C:24]3[O:30][C@@H:21]4[C@@:22]56[CH2:31][CH2:32][N:33]([CH3:34])[C@@H:16]([C@@H:17]5[CH:18]=[CH:19][C@:20]4([C:36](=[O:38])[CH3:37])[OH:35])[CH2:15][C:14]([C:23]6=3)=[CH:13]2)=[CH:6][CH:5]=1)([OH:3])=[O:2].C(Cl)Cl.CO.O.C(O)(=O)C>[OH-].[Na+]>[C:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]=[N:11][C:12]2[C:25]([OH:26])=[C:24]3[O:30][C@@H:21]4[C@@:22]56[CH2:31][CH2:32][N:33]([CH3:34])[C@@H:16]([C@@H:17]5[CH:18]=[CH:19][C@:20]4([C:36](=[O:38])[CH3:37])[OH:35])[CH2:15][C:14](=[C:23]63)[CH:13]=2)=[CH:6][CH:5]=1)([OH:3])=[O:2]