Dichloromethane methanol acetic acid water → 2-(4'Carboxyphenylazo)-6 acetyl morphine

Participants

Reaction Steps

A solution of 0.5g of 2-(4'carboxyphenylazo)-3,6-diacetylmorphine in 10 ml 0.1 N NaOH was stirred at room temperature and examined hourly by silica gel TLC for the presence of the monoacetyl derivative, the solvent system being methylene chloride: methanol: water: acetic acid (80:20:1:1) and the rf value for azomonoacetyl morphine 0.39. When TLC showed most of the starting material to have hydrolyzed the reaction mixture was concentrated and passed down a silica gel column. The fraction containing the desired product was evaporated to dryness to give 2-(4'carboxyphenylazo) -6 acetyl morphine.

Provenance & Evidence