Sodium Hydroxide → 2-Piperazinyl-4-butyl-thiazole

HRID 461779Notes

Reaction equation

HRID 461779 reaction equation
CN1CCN(C(N)=S)[CH2:4][CH2:3]1.N1(C(N)=S)CCNCC1.Cl.Cl.[N:22]1([C:28]2[S:29][CH:30]=[C:31]([C:33]([CH3:36])(C)C)[N:32]=2)[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1.[OH-].[Na+]>>[N:22]1([C:28]2[S:29][CH:30]=[C:31]([CH2:33][CH2:36][CH2:3][CH3:4])[N:32]=2)[CH2:23][CH2:24][NH:25][CH2:26][CH2:27]1

Participants

5

Reactant 4

HCID 14798Sodium HydroxideHCID 21130864-Methylpiperazine-1-carbothioamideHCID 47396381-PiperazinecarbothioamideHCID 1317109752-Piperazinyl-4-tert.buty-thiazole dihydrochloride

Product 1

HCID 706369952-Piperazinyl-4-butyl-thiazole

Procedure

By using the process described in Example 1, but replacing 4-methyl-1-piperazinyl-thiocarboxamide by an equivalent amount of 1-piperazinyl-thiocarboxamide, 2-piperazinyl-4-tert.buty-thiazole dihydrochloride, having a M.P. of 190°-196°, is obtained. The free base is obtained therefrom by treatment with an aqueous sodium hydroxide solution.

Workup

  1. customis obtained
  2. customThe free base is obtained

Sources & evidence

ORD record
ord-0bc4adcaff33408db60decdc036eae3f
Source dataset
uspto-grants-1977_12
Patent number
US04064244

Reaction notes

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