HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 2-Piperazinyl-4-butyl-thiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-Methylpiperazine-1-carbothioamide | HCID 2113086 | — |
| Reactant | 1-Piperazinecarbothioamide | HCID 4739638 | — |
| Reactant | 2-Piperazinyl-4-tert.buty-thiazole dihydrochloride | HCID 131710975 | — |
| Product | 2-Piperazinyl-4-butyl-thiazole | HCID 70636995 | — |
Reaction Steps
By using the process described in Example 1, but replacing 4-methyl-1-piperazinyl-thiocarboxamide by an equivalent amount of 1-piperazinyl-thiocarboxamide, 2-piperazinyl-4-tert.buty-thiazole dihydrochloride, having a M.P. of 190°-196°, is obtained. The free base is obtained therefrom by treatment with an aqueous sodium hydroxide solution.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04064244 |
| Source dataset | uspto-grants-1977_12 |
| ORD ID | ord-0bc4adcaff33408db60decdc036eae3f |
| Source note | uspto-grants-1977_12 |