Hydrochloric Acid → HCID 68125072, compound

HRID 461794Notes

Reaction equation

HRID 461794 reaction equation
[C:1]([N:4]1[CH2:49][CH2:48][CH2:47][C@H:5]1[C:6]([NH:8][C@H:9]([C:11]([N:13]1[CH2:46][CH2:45][CH2:44][C@H:14]1[C:15]([NH:17][N:18]([C:20]([O:22][CH:23]([C:39]([O:41][CH2:42][CH3:43])=[O:40])[CH2:24][CH2:25][CH2:26][CH2:27][NH:28]C(OCC1C=CC=CC=1)=O)=[O:21])[CH3:19])=[O:16])=[O:12])[CH3:10])=[O:7])(=[O:3])[CH3:2].[ClH:50].[H][H]>[Pd]>[ClH:50].[C:1]([N:4]1[CH2:49][CH2:48][CH2:47][C@H:5]1[C:6]([NH:8][C@H:9]([C:11]([N:13]1[CH2:46][CH2:45][CH2:44][C@H:14]1[C:15]([NH:17][N:18]([C:20]([O:22][CH:23]([C:39]([O:41][CH2:42][CH3:43])=[O:40])[CH2:24][CH2:25][CH2:26][CH2:27][NH2:28])=[O:21])[CH3:19])=[O:16])=[O:12])[CH3:10])=[O:7])(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 68124840HCID 68124840, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 68125072HCID 68125072, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A mixture of 0.01 moles of 5-benzyloxycarbonylamino1-ethoxycarbonylpentyl acetylprolylalanylprolyl-2-azaalaninate and 0.2 gm of 10% Pd/C in 200 ml of 1.0 N-ethanolic hydrogen chloride is hydrogenated at room temperature. When the required amount of hydrogen has been taken up the reaction mixture is filtered and concentrated in vacuo to give 5-amino-1-ethoxycarbonylpentyl acetylprolylalanylprolyl-2-azaalaninate hydrochloride.

Workup

  1. customis hydrogenated at room temperature
  2. filtrationis filtered
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-41e01f2bae2d4f15be2c73f707d285c3
Source dataset
uspto-grants-1977_12
Patent number
US04064236

Reaction notes

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