Methyl iodide → HCID 86735298, compound

HRID 461813Notes

Reaction equation

[N+:1]([C:4]1[C:5]2[CH2:6][C@H:7]3[CH2:16][S:15][C:14](=[S:17])[N:8]3[CH2:9][C:10]=2[CH:11]=[CH:12][CH:13]=1)([O-:3])=[O:2].[CH3:18][I:19]>>[I-:19].[CH3:18][S:17][C:14]1[S:15][CH2:16][C@@H:7]2[CH2:6][C:5]3[C:4]([N+:1]([O-:3])=[O:2])=[CH:13][CH:12]=[CH:11][C:10]=3[CH2:9][N+:8]=12

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 54444031HCID 54444031, compound

Product 1

HCID 86735298HCID 86735298, compound

Procedure

(S)-9-Nitro-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinoline-3-thione (40 g.) is dissolved in methyl iodide (100 cc.). After 48 hours at a temperature of about 20° C., the crystals which have appeared are filtered off, washed with diethyl ether (2 × 30 cc.) and then dried at 20° C under reduced pressure (1 mm. Hg). (S)-3-Methylthio-9-nitro-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinolinium iodide (6.0 g.) is thus obtained.

Workup

filtrationthe crystals which have appeared are filtered off
washwashed with diethyl ether (2 × 30 cc.)
customdried at 20° C under reduced pressure (1 mm. Hg)

Sources & evidence

ORD record: ord-8b62882be1674afe9fa59fc9637474fe
Source dataset: uspto-grants-1977_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04064247

Reaction notes

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