Methyl iodide → HCID 86735298, compound

Participants

Reaction Steps

(S)-9-Nitro-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinoline-3-thione (40 g.) is dissolved in methyl iodide (100 cc.). After 48 hours at a temperature of about 20° C., the crystals which have appeared are filtered off, washed with diethyl ether (2 × 30 cc.) and then dried at 20° C under reduced pressure (1 mm. Hg). (S)-3-Methylthio-9-nitro-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinolinium iodide (6.0 g.) is thus obtained.

Provenance & Evidence