p-Toluenesulfonic acid → HCID 21392829, compound

HRID 461850Notes

Reaction equation

HRID 461850 reaction equation
[CH3:1][C:2]1[N:9]2[C:5]([S:6][C:7]3[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=32)=[N:4][N:3]=1.[C:14]1([CH3:24])[CH:19]=[CH:18][C:17]([S:20]([OH:23])(=[O:22])=[O:21])=[CH:16][CH:15]=1>C(O)C>[C:14]1([CH3:24])[CH:15]=[CH:16][C:17]([S:20]([OH:23])(=[O:21])=[O:22])=[CH:18][CH:19]=1.[CH3:1][C:2]1[N:9]2[C:5]([S:6][C:7]3[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=32)=[N:4][N:3]=1

Participants

4

Reactant 2

HCID 6101p-Toluenesulfonic acidHCID 2531443-Methyl(1,2,4)triazolo(3,4-b)(1,3)benzothiazole

Product 1

HCID 21392829HCID 21392829, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
90 °C

Procedure

3-Methyl-s-triazolo(3,4-b)benzothiazole (2 grams) was dissolved in 50 milliliters of ethanol. To this solution, 2 grams of p-toluenesulfonic acid were added, with stirring. After thorough mixing, the reaction mixture was heated to 90° C. and maintained at 90° C. for 1 hour. Solvent was thereafter removed under reduced pressure, yielding the desired salt as a solid. It was recrystallized from ethanol, m.p., 163°-4° C. NMR confirmed its identity. After a second recrystallization from ethanol, elemental analysis showed the following:

Workup

  1. temperaturemaintained at 90° C. for 1 hour
  2. customSolvent was thereafter removed under reduced pressure

Sources & evidence

ORD record
ord-50a8207c109f4f52b9129ffcd7a3e7d5
Source dataset
uspto-grants-1977_12
Patent number
US04064261

Reaction notes

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