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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 461871Generated: October 27, 2026

Malononitrile → Tyrphostin AG 1024

https://huagongshe.com/reaction/461871

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMalononitrileHCID 8010—
Reactant3-Bromo-5-tert-butyl-4-hydroxybenzaldehydeHCID 14839297—
ProductTyrphostin AG 1024HCID 2044—

Reaction Steps

In a similar manner as described in Example 2 reaction of 3-bromo-5-tert-butyl-4-hydroxybenzaldehyde and malononitrile gave 3-bromo-5-tert-butyl-4-hydroxybenzylidenemalononitrile as pale yellow needles from alcohol m.p. 185°.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04064266
Source datasetuspto-grants-1977_12
ORD IDord-8017d5d322bd4ba09e4c0cc84ea464ff
Source noteuspto-grants-1977_12