Malononitrile → Tyrphostin AG 1024

HRID 461871Notes

Reaction equation

HRID 461871 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([C:11]([CH3:14])([CH3:13])[CH3:12])[C:9]=1[OH:10])[CH:5]=O.[C:15](#[N:19])[CH2:16][C:17]#[N:18]>>[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([C:11]([CH3:14])([CH3:13])[CH3:12])[C:9]=1[OH:10])[CH:5]=[C:16]([C:15]#[N:19])[C:17]#[N:18]

Participants

3

Reactant 2

HCID 8010MalononitrileHCID 148392973-Bromo-5-tert-butyl-4-hydroxybenzaldehyde

Product 1

HCID 2044Tyrphostin AG 1024

Procedure

In a similar manner as described in Example 2 reaction of 3-bromo-5-tert-butyl-4-hydroxybenzaldehyde and malononitrile gave 3-bromo-5-tert-butyl-4-hydroxybenzylidenemalononitrile as pale yellow needles from alcohol m.p. 185°.

Sources & evidence

ORD record
ord-8017d5d322bd4ba09e4c0cc84ea464ff
Source dataset
uspto-grants-1977_12
Patent number
US04064266

Reaction notes

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