Diethylamine → HCID 21392868, compound

HRID 461883Notes

Reaction equation

HRID 461883 reaction equation
Cl.Br[CH:3]([CH3:19])[C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([N:13]=[C:14]([N:16]([CH3:18])[CH3:17])[CH3:15])=[CH:9][CH:8]=1)=[O:5].[CH2:20]([NH:22][CH2:23][CH3:24])[CH3:21]>>[CH2:20]([N:22]([CH2:23][CH3:24])[CH:3]([CH3:19])[C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([N:13]=[C:14]([N:16]([CH3:18])[CH3:17])[CH3:15])=[CH:9][CH:8]=1)=[O:5])[CH3:21]

Participants

3

Reactant 2

HCID 8021DiethylamineHCID 21392895HCID 21392895, compound

Product 1

HCID 21392868HCID 21392868, compound

Procedure

Following the procedure described in Example 3, reaction of 27.5 g of N'[4-(α-bromopropionyl)aminophenyl]-N,N-dimethylacetamidine hydrochloride with 40 g of diethylamine gives N'-[4-(α-diethylaminopropionyl)aminophenyl]-N,N-dimethylacetamidine, which is converted, in the crude form, into the naphthalenedisulphonate by means of one equivalent of naphthalenedisulphonic acid. Yield 16 g, melting point >260° C (decomposition) (recrystallized from ethanol/H2O).

Sources & evidence

ORD record
ord-8bdbd95bf37e452d927d44fbead06bae
Source dataset
uspto-grants-1977_12
Patent number
US04064270

Reaction notes

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