Hydrochloric Acid → 9H-Fluoren-9-one, 2,7-bis(1-oxo-4-(1-piperidinyl)butyl)-, dihydrochloride

HRID 461965Notes

Reaction equation

HRID 461965 reaction equation
[N:1]1([CH2:7][CH2:8][CH2:9][C:10]([C:12]2[CH:24]=[CH:23][C:22]3[C:21]4[C:16](=[CH:17][C:18]([C:25](=[O:35])[CH2:26][CH2:27][CH2:28][N:29]5[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]5)=[CH:19][CH:20]=4)[C:15](=[O:36])[C:14]=3[CH:13]=2)=[O:11])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:37]>C(Cl)(Cl)Cl>[ClH:37].[ClH:37].[N:1]1([CH2:7][CH2:8][CH2:9][C:10]([C:12]2[CH:24]=[CH:23][C:22]3[C:21]4[C:16](=[CH:17][C:18]([C:25](=[O:35])[CH2:26][CH2:27][CH2:28][N:29]5[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]5)=[CH:19][CH:20]=4)[C:15](=[O:36])[C:14]=3[CH:13]=2)=[O:11])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 1475842,7-Bis(1-oxo-4-(1-piperidyl)butyl)-9H-fluoren-9-one

Product 1

HCID 1475839H-Fluoren-9-one, 2,7-bis(1-oxo-4-(1-piperidinyl)butyl)-, dihydrochloride

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

2,7-Bis(4-piperidinobutyryl)fluoren-9-one, prepared in Example 33, was dissolved in chloroform and the resulting solution acidified with ethereal HCl to give the desired product which was recrystallized once from water-isopropyl alcohol. M.P. 322°-323° C, λMaxH2O 284, E1cm1% 1,220.

Sources & evidence

ORD record
ord-406852c9f0104ce28964ecd8b87b1353
Source dataset
uspto-grants-1977_12
Patent number
US04064347

Reaction notes

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