反应详情

87 ml (0.2 mole) ethanolic sodium ethylate solution are added to 41 g (0.2 mole) 2-chloroethanephosphonic acid N-monoisopropylamide chloride in 200 ml benzene at room temperature. Stirring was afterwards effected for 2 hours; the salts were then filtered off with suction, the reaction solution was washed with water, and drying with sodium sulfate was effected. After the solvent had been drawn off, slight distillation was carried out. There remained behind a colourless oil, nD26 = 1.4580, yield: 27 g (64%) 2-chloroethanephosphonic acid ethyl ester N-monoisopropylamide.

1. filtrationthe salts were then filtered off with suction
2. washthe reaction solution was washed with water
3. dry with materialdrying with sodium sulfate
4. distillationslight distillation