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HRID462023

反应详情

EQUATION

反应方程式

HRID 462023 的结构方程式

REACTANTS

反应物

2
反应SMILES：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

反应SMILES：COC(=O)[C@@H]1[C@H]2CC[C@@H](C[C@@H]1O)N2C.Cl
HCID162352

Methyl 3-hydroxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate--hydrogen chloride (1/1)

C10H18ClNO3

PRODUCTS

产物

1
反应SMILES：COC(=O)[C@@H]1[C@H]2CC[C@@H](C[C@@H]1O)N2C
HCID104904

Ecgonine methyl ester

C10H17NO3

AUXILIARIES

试剂、催化剂与溶剂

1
反应SMILES：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

To 20ml of cold saturated potassium carbonate solution in a 125ml separator funnel was added a solution of 5.0g (213 mmoles) ecgonine methyl ester hydrochloride in 5ml water. The aqueous mixture was extracted with 4 × 60ml of chloroform. The combined chloroform extracts were dried over anhydrous sodium carbonate and evaporated in vacuo. Pumping at 0.05mm Hg for 15 minutes yielded 4.0g (93%) of TLC pure (20:1 CHCl3 :MeOH) ecgonine methyl ester.

WORKUP

后处理

  1. extractionThe aqueous mixture was extracted with 4 × 60ml of chloroform
  2. dry with materialThe combined chloroform extracts were dried over anhydrous sodium carbonate
  3. customevaporated in vacuo