HRID46210
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 70 °C
PROCEDURE
实验过程
Sodium hydroxide (40 mg, 0.81 mmol) was added to methyl 2-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl)phenyl)-2-(7-methylbenzo[e][1,2,4]triazin-3-yl)acetate (compound 62, 228 mg, 0.27 mmol) in the mixture of THF, MeOH and water (9/1/1 ratio) at room temperature, and then the mixture was stirred at 70° C. for a 1 day until starting material was disappeared. After reaction complete, the solution was work-up with CH2Cl2. After evaporating the volatile solvent, silica gel column chromatography (Hx/EtOAc=⅓) gave the desired compound (115 mg, 73% yield) as light yellow oil.
WORKUP
后处理
- customAfter reaction complete
- customAfter evaporating the volatile solvent, silica gel column chromatography (Hx/EtOAc=⅓)