HCID 21824583, compound → HCID 21824585, compound

HRID 462105Notes

Reaction equation

HRID 462105 reaction equation
[CH2:1]([NH:8][CH2:9][CH2:10][C:11]1[CH:16]=[C:15]([O:17][CH3:18])[C:14]([O:19][CH3:20])=[CH:13][C:12]=1[CH2:21][C:22]([OH:24])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C1(C)C(C)=CC=CC=1>[CH2:1]([N:8]1[C:22](=[O:24])[CH2:21][C:12]2[CH:13]=[C:14]([O:19][CH3:20])[C:15]([O:17][CH3:18])=[CH:16][C:11]=2[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 21824583HCID 21824583, compound

Product 1

HCID 21824585HCID 21824585, compound

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

A stirred suspension of 4.1 suspension of 4.1 g of the benzylamino acid obtained in Example 22 was refluxed in 75 ml. of xylene under a Dean-Stark trap for 24 hours, at the end of which time a clear solution had resulted. Distillation of the xylene in vacuo left the above-named product as shining white plates, m.p. 141°-142°. A sample of the cyclic lactam recrystallized from toluene melted at 141°-142°.

Workup

  1. temperaturewas refluxed in 75 ml
  2. customat the end of which time a clear solution had resulted
  3. distillationDistillation of the xylene in vacuo
  4. waitleft the above-named product
  5. customA sample of the cyclic lactam recrystallized from toluene melted at 141°-142°

Sources & evidence

ORD record
ord-783cd742514f45888347dbd1eec43ac8
Source dataset
uspto-grants-1977_12
Patent number
US04065473

Reaction notes

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