反应详情

To a solution of 2-thiopheneamidoxime (10 g, 0.07 mole) and p-nitrobenzoyl chloride (13 g, 0.07 mole) in 400 ml of dry dioxane, 1 ml of BF3 -ethyl ether is added and the mixture is heated to reflux for 16 hours. Evaporation of the solvent in vacuo gives a dark solid. It is decolorized by treating with Darco (CHCl3). The solvent is concentrated in vacuo and the product is crystallized from ethanol to give 12.5 g (65%) of product, m.p. 169°-171°.

1. temperaturethe mixture is heated
2. temperatureto reflux for 16 hours
3. customEvaporation of the solvent in vacuo
4. customgives a dark solid
5. concentrationThe solvent is concentrated in vacuo
6. customthe product is crystallized from ethanol