Sodium Bicarbonate → 2-(2-Formamido-5-thiadiazolyl)-1-methyl-5-nitroimidazole

HRID 462217Notes

Reaction equation

HRID 462217 reaction equation
[NH2:1][N:2]1[NH:6][CH:5]=[C:4]([C:7]2[N:8]([CH3:15])[C:9]([N+:12]([O-:14])=[O:13])=[CH:10][N:11]=2)[S:3]1.[C:16](=O)(O)[O-:17].[Na+]>C(O)=O>[CH:16]([NH:1][N:2]1[NH:6][CH:5]=[C:4]([C:7]2[N:8]([CH3:15])[C:9]([N+:12]([O-:14])=[O:13])=[CH:10][N:11]=2)[S:3]1)=[O:17]

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 213908162-(2-Amino-5-thiadiazolyl)-1-methyl-5-nitroimidazole

Product 1

HCID 213908602-(2-Formamido-5-thiadiazolyl)-1-methyl-5-nitroimidazole

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

The above compound is prepared by refluxing 8 gm. of 2-(2-amino-5-thiadiazolyl)-1-methyl-5-nitroimidazole in 30 ml. of 98% formic acid for 10 hours, cooling, and adding the mixture to saturated sodium bicarbonate solution, and the solid collected. The compound melts at 225° to 227° C.

Workup

  1. customThe above compound is prepared
  2. temperatureby refluxing 8 gm
  3. temperaturecooling
  4. customthe solid collected

Sources & evidence

ORD record
ord-a50a6ee715ff48a4be8eb8c251d2bf62
Source dataset
uspto-grants-1977_12
Patent number
US04065567

Reaction notes

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