反应详情

A mixture consisting of 3.8 gm., 0.0l55 mole of 2-(2-chloro- 5-thiadiazolyl)-1-methyl-5-nitroimidazole, prepared as in Example 16 2.5 gm., 0.029 mole of 3-dimethylaminopropylamine, 2.1 gm. 0.025 mole, of sodium bicarbonate and 100 ml. of benzene is refluxed for twenty-two hours. The reaction mixture is cooled to room temperature, washed with aqueous sodium bicarbonate and sodium chloride solutions. Cooling to 5° C. gives a crystalline precipitate which is collected and recrystallized from benzene to give the pure compound melting at 153°-154° C. More product is obtained from the mother liquors to give an overall yield of 3.0 gm.

1. washwashed with aqueous sodium bicarbonate and sodium chloride solutions
2. temperatureCooling to 5° C.
3. customgives a crystalline precipitate which
4. customis collected
5. customrecrystallized from benzene