Hydrochloric Acid → 2-(2-Amino-5-thiadiazolyl)-1-methyl-5-nitroimidazole Hydrochloride

HRID 462227Notes

Reaction equation

HRID 462227 reaction equation
[NH2:1][N:2]1[NH:6][CH:5]=[C:4]([C:7]2[N:8]([CH3:15])[C:9]([N+:12]([O-:14])=[O:13])=[CH:10][N:11]=2)[S:3]1.[ClH:16]>>[ClH:16].[NH2:1][N:2]1[NH:6][CH:5]=[C:4]([C:7]2[N:8]([CH3:15])[C:9]([N+:12]([O-:14])=[O:13])=[CH:10][N:11]=2)[S:3]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 213908162-(2-Amino-5-thiadiazolyl)-1-methyl-5-nitroimidazole

Product 1

HCID 213908152-(2-Amino-5-thiadiazolyl)-1-methyl-5-nitroimidazole Hydrochloride

Procedure

Four grams of 2-(2-amino-5-thiadiazolyl)-1-methyl-5-nitroimidazole is added to concentrated hydrochloric acid. The resultant precipitate of the hydrochloride is filtered off and air dried; melting point 249° C. with decomposition. When the hydrochloride is added to water, the free base is formed again without the necessity of using alkali.

Workup

  1. filtrationThe resultant precipitate of the hydrochloride is filtered off
  2. customair dried
  3. additionWhen the hydrochloride is added to water
  4. customthe free base is formed again without the necessity of using alkali

Sources & evidence

ORD record
ord-885e96e43cfd40c5b7bab7b1a1a3c3ce
Source dataset
uspto-grants-1977_12
Patent number
US04065567

Reaction notes

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