Methyl Isocyanate → HCID 13150547, compound

HRID 462330Notes

Reaction equation

HRID 462330 reaction equation
[OH:1][N:2]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:3]([NH:5][C:6]1[S:10][N:9]=[N:8][CH:7]=1)=[O:4].[CH3:17][N:18]=[C:19]=[O:20]>C(N(CC)CC)C>[CH3:17][NH:18][C:19]([O:1][N:2]([C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[C:3]([NH:5][C:6]1[S:10][N:9]=[N:8][CH:7]=1)=[O:4])=[O:20]

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 13150545HCID 13150545, compound

Product 1

HCID 13150547HCID 13150547, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineCatalyst

Procedure

4.72 g (0.02 mole) 1-hydroxy-1-phenyl-3-(1,2,3-thiadiazole-5-yl)-urea were suspended in 40 ml tetrahydrafuran and then reacted with 1.19 ml (0.02 mole) methylisocyanate. After addition of 3 drops of triethylamine there is obtained a clear solution and after a further 10 minutes crystals already begin to separate out. The reaction mixture is allowed to stand at room temperature. Thereafter the crystals are separated off and digested with diisopropylether.

Workup

  1. customthere is obtained a clear solution
  2. customto separate out
  3. customto stand at room temperature
  4. customThereafter the crystals are separated off

Sources & evidence

ORD record
ord-c636a19b75a64cf8b00af030d57cae22
Source dataset
uspto-grants-1985_05
Patent number
US04515619

Reaction notes

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