4,4'-Dichlorobutyrophenone → 1-(4-Chlorophenyl)-4-[4-[3-chloro-4-(hydroxymethyl)phenyl]-1-piperazinyl]-1-butanone

Participants

Reaction Steps

A solution of 4,4'-dichlorobutyrophenone (4.5 g, 20.7 mmole) in 25 ml of acetone was added to a warm suspension of 2-chloro-4-(1-piperazinyl)benzenemethanol (4.7 g, 20.7 mole) in 50 ml acetone and 2.5 ml of triethylamine. The reaction mixture was refluxed for four days, cooled at -10° for three hours, and then filtered. The product was washed with a little acetone, triturated on the filter with water (four times, 50 ml), and air dried. Recrystallization from acetonitrile (65 ml) gave 3.0 g (35%), mp 137°-139°.

Provenance & Evidence