反应详情

A solution of 4,4'-dichlorobutyrophenone (4.5 g, 20.7 mmole) in 25 ml of acetone was added to a warm suspension of 2-chloro-4-(1-piperazinyl)benzenemethanol (4.7 g, 20.7 mole) in 50 ml acetone and 2.5 ml of triethylamine. The reaction mixture was refluxed for four days, cooled at -10° for three hours, and then filtered. The product was washed with a little acetone, triturated on the filter with water (four times, 50 ml), and air dried. Recrystallization from acetonitrile (65 ml) gave 3.0 g (35%), mp 137°-139°.

1. temperatureThe reaction mixture was refluxed for four days
2. temperaturecooled at -10° for three hours
3. filtrationfiltered
4. washThe product was washed with a little acetone
5. customtriturated on the
6. filtrationfilter with water (four times, 50 ml), and air
7. customdried
8. customRecrystallization from acetonitrile (65 ml)
9. customgave 3.0 g (35%), mp 137°-139°