HRID46251

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID887

Methanol

CH4O

结构：COc1ccc(CN(c2nncs2)S(=O)(=O)c2cc(Cl)c(F)cc2F)c(OC)c1

HCID58042253

未命名化合物

结构：CC(C)(C)n1cc(-c2cc(Cl)ccc2O)c(NC(=O)C(F)(F)F)n1

HCID86643821

Acetamide, N-[4-(5-chloro-2-hydroxyphenyl)-1-(1,1-dimethylethyl)-1H-pyrazol-3-yl]-2,2,2-trifluoro-

C15H15ClF3N3O2

PRODUCTS

生成物

结构：Nc1[nH]ncc1-c1cc(Cl)ccc1Oc1cc(F)c(S(=O)(=O)Nc2nncs2)cc1Cl

HCID46841217

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID313

Hydrochloric Acid

ClH

PROCEDURE

实验过程

The title compound was prepared from N-[1-tert-Butyl-4-(5-chloro-2-hydroxyphenyl)-1H-pyrazol-3-yl]-2,2,2-trifluoroacetamide (Preparation 209) and 5-chloro-N-(2,4-dimethoxybenzyl)-2,4-difluoro-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide (Preparation 247) using Method B above with the exception that heating at 55° C. in HCl (gas) saturated methanol for 16 hours was used to remove the protecting groups. Purification by preparative HPLC afforded the title compound.

WORKUP

后处理

customto remove the protecting groups
customPurification by preparative HPLC